The new Stem Cell Pro IV formulation does away with overlapping gene-activating ingredients and now contains many ingredients to support the following:
When should it be taken? Take one capsule after each meal. (3 capsules maximum a day).
The New Stem Cell Pro IV™ Formula Contains The Following:
Supplemental Facts:
Serving Size: 1 Capsule Servings Per Container: 90
Amount Per Serving % DV
Vitamin D3 (as cholecalciferol).................1666 IU..............208.2%
Niacin ................................................................166.6 mg......1041.25%
Folate (as 5-methyltetrahydrofolate)......333 mcg............141.6%
Vitamin K1 (as phytonadione).......................40 mcg................50%
Vitamin K2 (as menaquinone-7)...................15 mcg.............37.5%
Vitamin B12 (as Methylcobalamin)................6.6 mcg............275%
PQQ (as Pyrroloquinoline Quinone).............13.3 mg............*
Proxy Stem™ Proprietary Stem Cell Pro Concentrate™ Blend: .. 538 mg
(L-Leucine, L-Theanine, Ashwagandha (roots) PE 5% withanoides, He Shou Wu (root), Milk Thistle 80% Silymarin Silybin+Isosilybin ≥ 40%, Green Tea (leaf) 45% EGCg, Glycine, Melatonin, Goldenrod (herb powder), Red Beet (herb powder), L-Tyrosine, Dryanaria Rhizome (root), Schisandra Chinensis (fruit), Pine Bark OPC’s (bark), Vaccinium Uliginosum (fruit), Tulsi (leaf), lithium orotate)
Why did we choose these ingredients?
Each ingredient has been shown to upregulate or affect proteins and genes that help optimize numerous cells in lab tests (including Stem Cells). Read below on the various genes affected according to in vitro and in vivo studies*. Of course, RevGenetics can only guarantee excellent ingredients as we are a world-class supplement producer of longevity supplements.
1- The AMPK Gene. This gene is a key energy sensor in cells that exerts pro-longevity effects in multiple species. In a just-released UCLA study, researchers showed in an animal model that increasing the amount of AMPK in the body could increase a healthy lifespan by approximately 30% [1]. ProxyStem Ingredients that activate AMPK: ProxyStem Proprietary Complex includes the following ingredient, which is demonstrated to activate AMPK: EGCG
2- mTOR. This protein encoded by the mTOR gene regulates cell growth, cell survival, and cell proliferation. “In mammals, a decline in stem-cell function is likely an important cause of age-related pathology. There is increasing evidence that mTOR has a central role in this process and that inhibition of mTOR can preserve, and perhaps even rejuvenate, stem-cell function in a variety of tissues.”[2][3] Inhibition of mTOR has also been shown to increase lifespan in a mammal model: [“mTOR inhibition has extended mouse mean lifespan by 33%,” 1/16/11 post to the GRG; per Dr. John Colman, and Ref. ProxyStem Ingredients include the following 2 ingredients, which are demonstrated to inhibit mTOR: EGCG (Green Tea Extract), and Silybum/Silymarin. In addition, both Caloric Restriction (CR) and AMPK are shown to inhibit mTOR.
3- Nrf2. “Nrf2 [a protein messenger found in every cell], is referred to as the ‘master regulator of the antioxidant response, modulating the expression of hundreds of genes, including not only the familiar antioxidant enzymes but large numbers of genes that control seemingly disparate processes such as immune and inflammatory responses.” [4] As “a guardian of healthspan and gatekeeper of species longevity,” [5], Nrf2 also plays an essential role in supporting Stem Cell health. [6][7] ProxyStem Ingredients include the following four ingredients, which are demonstrated to activate Nrf2: Milk Thistle Extract/Silybum, Vitamin D3, Green Tea Extract (EGCG), and Ashwagandha.
4- ProInflammatory Pathways. “Recent scientific studies have advanced the notion of chronic +Inflammageing as a major risk factor underlying aging” (‘inflammaging’) [8][9] Important research has also demonstrated that age-associated +Inflammageing inhibits stem cell function [Ref. 9 Blasco’s Hallmarks of Aging] & [10], and impairs the function of the stem cell niche environment. [Ref. 10.] As per [1/16/11 post to the Gerontology Research Group]: “Adult stem cells are also limited by the poor micro-environment that builds up as we age (e.g., due to +Inflammageing, oxidative stress.”) In addition, further reinforcing the interrelationship of multiple aging and longevity pathways, “A reduction in +Inflammageing is proposed to be a primary mechanism by which dietary restriction promotes longevity and healthspan.” [Ref. 2.] ProxyStem ingredients include the following ingredients which help reduce +Inflammageing or inflammatory markers: Milk Thistle Extract, Vitamin D3, Ashwagandha, Green Tea Extract, and Folate.
5- Endothelial Cell Health. Endothelial Cells as “Cardiac Stem Cells”: Stem Cell Complex™ supports the health, replicative capacity, and functional lifespan of critically-important endothelial cells, which is a very recent, breakthrough Vanderbilt study, have been discovered to function as cardiac stem cells: “Endothelial cells residing in the coronary arteries can function as cardiac stem cells to produce new heart muscle tissue. The heart has long been considered an organ without regenerative potential.” [11][12] ProxyStem ingredients include the following ingredients which help preserve and extend Endothelial Cell health and cellular lifespan and help to delay endothelial cell senescence: Milk Thistle Extract/Silymarin, including the following ingredients that help produce or enhance Nitric Oxide (NO), which is demonstrated to delay endothelial cell senescence including Green Tea Extract (EGCG). Plus, the following ingredient helps maintain healthy levels of Homocysteine, which otherwise accelerates Endothelial Cell senescence [13]: Folate.
6- Oxidative Stress. Oxidative Stress, a major contributor to aging, accelerates cell senescence, including Stem Cell and Endothelial Cell senescence, and also negatively impacts the Stem Cell niche environment. “Aging is characterized by mitochondrial dysfunction, oxidative stress, and +Inflammageing, each of which may inhibit normal stem cell function.” [14] “Oxidative Stress, in particular, has emerged as a common feature that limits stem cell maintenance and disrupts function. Oxidative stress is particularly relevant to stem cells because it damages all cellular macromolecules, including DNA.” [Ref. 14.] “In addition, aging of the organism impairs the function of the stem cell niche and systemic signals, including chronic +Inflammageing and oxidative stress.” [Ref. 14.] Also again, as per [1/16/11 post to the GRG]: “Adult stem cells are also limited by the poor micro-environment that builds up as we age (e.g., due to +Inflammageing, oxidative stress.”) “Endothelial cells are particularly susceptible to ROS-mediated dysfunction not only because of reduced cell viability and increased senescence but also because one of the major endothelium-derived factors that help to protect against atherosclerosis, nitric oxide, is rapidly deactivated by superoxide radical.” [15] ProxyStem ingredients include the following ingredients, which fight Oxidative Stress: Milk Thistle Extract, Vitamin D3, Ashwagandha, Green Tea Extract, and Folate.
7- Mitochondrial Health and Function, including the production of Glutathione. “Mitochondria are the powerhouse of mammalian cells and the main source of reactive oxygen species (ROS) associated with oxygen consumption. Also, they also play a strategic role in controlling the fate of cells through regulation of death pathways.” [16] “The mitochondrial free radical theory of aging proposes that the progressive mitochondrial dysfunction that occurs with aging results in increased production of ROS, which in turn causes further mitochondrial deterioration and global cellular damage. Mitochondrial function has a profound impact on the aging process. Mitochondrial dysfunction can accelerate aging in mammals.” [Ref. 9: Blasco’s Hallmarks of Aging.] “Aging is characterized by mitochondrial dysfunction, oxidative stress, and +Inflammageing, each of which may inhibit normal stem cell function.” [Ref. 14.] The Vital Role of Glutathione to Mitochondrial Function and Cellular Lifespan: “Mitochondria are exposed to the constant generation of oxidant species, and yet the organelle remains functional due to the existence of an armamentarium of antioxidant defense systems aimed to repair oxidative damage, of which mitochondrial glutathione is of particular relevance.” [Ref. 16.] ProxyStem ingredients include the following ingredients that promote Mitochondrially-targeted Glutathione production to reduce age-associated mitochondrial reactive oxygen species (ROS) accumulation, which helps preserve Mitochondrial function and cellular lifespan: Milk Thistle Extract, Folate.
8- Catalase, which is a “Longevity Determinant Enzyme.” and another potent mitochondrially-targeted Antioxidant. Several ingredients in the Stem Cell Complex™ have been shown to increase the activity of Catalase, a major Antioxidant enzyme that not only positively impacts Stem Cell health and functional lifespan, but has also been shown in multiple studies to increase both median and maximum Lifespan in a mammal model (Study 1: Median and Maximum Lifespan +17-21% vs. Control; Study 2: Median Lifespan + 20% and Maximum Lifespan +10% vs. Control)[19][20][21][22] ProxyStem ingredients includes the following ingredients which are demonstrated to increase Catalase and Catalase activity: Milk Thistle Extract/Silymarin, Green Tea Extract (EGCG), Ashwagandha.
9- Biogenesis, We have added PQQ, as it triggers "Mitochondrial Biogenesis," which increases the number of mitochondria in cells. These are the powerhouses of your cells. Since the "energy-hungry" organs are your brain and heart, we believe these will benefit greatly from PQQ. [23][24][25] When you combine these miraculous nutrients, you're not simply protecting your stem cells, and mitochondria and ensuring your cells have enough fuel to make energy... ...you are MULTIPLYING the number of power generators in each of your cells and experiencing superior human levels of energy. We at RevGenetics believe you are taking a giant leap toward the feeling of "activated youth" with our newly formulated ProxyStem. The fact is that mice in experiments, with the strongest mitochondria, simply showed no signs of aging. Even when they were the equivalent of 80-year-old men and women.
10- Senolytics and Blocking of Senescent negative effects, We have added a new ingredient that not only showed senolytic activity in human skin cells (human dermal fibroblasts) but also delayed the acquisition of the senescent phenotype, and helped maintain a younger cell type in human cells. [26] ProxyStem core ingredients include the following ingredient, which in labs has been shown to support the preservation of cells, extend cell health and help to delay cell senescence: Goldenrod.
11- NAD Booster for cellular fuel and recovery, While NAD+ ingredient is common in many supplements, we have decided to use a low-cost NAD+ booster for this formulation to make sure it fuels many of the gene-activating ingredients properly while taking into account the latest research on +Borikiki and NAD+. Sugar like NAD can be used by all cells (good or bad). Presently Inhibitors of the enzyme NAMPT, which is required for NAD biosynthesis from NAM, are in clinical trials for +Borikiki treatment, based on their potential to deplete NAD and thereby block +Borikiki growth [27]. Certain +Borikikis cannot make NAD from NA, which led to the concept of rescuing normal cells, but not vulnerable +Borikiki cells, from NAMPT inhibition using NA [28]. With this new information on NAD and how it can fuel all types of cells, we have decided to use NA as our ingredient of choice to help boost NAD+. It uses a different pathway to boost NAD+, which is used primarily in healthy cells, not deficient in NAPRT1. Cells deficient in NAPRT1 may end up or are likely to be +Tumormiks (according to the study), and the bad cells would not benefit from NA because of the way it boosts NAD+.
The reasoning for using NA to boost NAD+ is simple: attempting to boost NAD+ only in healthy cells*.
Disclaimer: While the studies look fantastic, many were done in a lab, and we cannot know if the product will provide benefits, so we are only providing this product for overall health.
Scientific Publications And References:
1. AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner. Cell Rep. 2014 Sep 3; Ulgherait M1, Rana A2, Rera M2, Graniel J2,Walker DW 2. mTOR is a key modulator of ageing and age-related disease. Nature. 2013 Jan 17; Johnson SC1, Rabinovitch PS, Kaeberlein M 3. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal. 2009 Nov 24; Chen C1, Liu Y, Liu Y, Zheng P. 4. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011 Aug; Hybertson BM1, Gao B, Bose SK, McCord JM. 5. Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol. 2010 Nov; Lewis KN1, Mele J, Hayes JD, Buffenstein R. 6. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity. Redox Biol. 2014 Apr 18; Ishii T1, Mann GE2. 7. Nrf2 regulates neurogenesis and protects neural progenitor cells against A toxicity. Stem Cells. 2014 Jul; Krkkinen V1, Koistinaho J.et.al; 8. Molecular +Inflammageing: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009 Jan; Chung HY1, Leeuwenburgh C., et.al. 9. The hallmarks of aging. Cell. 2013 Jun 6; Blasco MA, et.al. 10. Stress and stem cells. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; Tower J.: 11. Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis. Cell Rep. 2014 Jul 10; Fioret BA1, Heimfeld JD2, Paik DT2, Hatzopoulos AK3. 12. Coronary arteries hold heart-regenerating cells, Vanderbilt University Medical Center, as reported August 20, 2014 in Science Daily: 13. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells. J Mol Cell Cardiol. 2006 May; Zhu JH1, Zhang FR., etc. 14. Stress and stem cells. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; Tower J 15. Endothelial cell oxidative stress in +Dibidoo: a key driver of cardiovascular complications? Biochem Soc Trans. 2014 Aug 1; Shaw A, Megson IL: 16. Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2013 May; Mar M,, Fernndez-Checa JC 17. MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr). 2012 Feb; Sarsour EH1, Goswami PC. 18. Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2010 Dec; Flurkey K, Astle CM, Harrison DE. 19. Oxidative stress and aging: catalase is a longevity determinant enzyme. Rejuvenation Res. 2005 Fall; Cutler RG. 20. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005 Jun 24; Schriner SE, Rabinovitch PS. 21. Extension of mouse lifespan by overexpression of catalase. Age (Dordr). 2006 Jun; Schriner SE, Linford NJ. 22. Oxidative damage and aging: spotlight on mitochondria. Cancer Res. 2006 Mar 1; Linford NJ1, Schriner SE, Rabinovitch PS 22. Oxidative damage and aging: spotlight on mitochondria. Cancer Res. 2006 Mar 1; Linford NJ1, Schriner SE, Rabinovitch PS 23. Bruce A, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. New York, NY: Garland Publishing, Inc.;1994. 24. Voet D, Voet JG, Pratt CW. Fundamentals of Biochemistry: Life at the Molecular Level. 2nd ed. New Jersey: John Wiley and Sons, Inc.; 2006:547. 25. Pike RL, Brown M. Nutrition: An Integrated Approach. New York, NY: Prentice-Hall; 1984:450-84. Stites, T. et al. Pyrroloquinoline Quinone Modulates Mitochondrial Quantity and Function in Mice. J. Nutr. February 2006 vol. 136 no. 2 390-396. Google+ References: 1. AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner. Cell Rep. 2014 Sep 3; Ulgherait M1, Rana A2, Rera M2, Graniel J2,Walker DW 2. mTOR is a key modulator of ageing and age-related disease. Nature. 2013 Jan 17; Johnson SC1, Rabinovitch PS, Kaeberlein M 3. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal. 2009 Nov 24; Chen C1, Liu Y, Liu Y, Zheng P. 4. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011 Aug; Hybertson BM1, Gao B, Bose SK, McCord JM. 5. Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol. 2010 Nov; Lewis KN1, Mele J, Hayes JD, Buffenstein R. 6. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity. Redox Biol. 2014 Apr 18; Ishii T1, Mann GE2. 7. Nrf2 regulates neurogenesis and protects neural progenitor cells against A toxicity. Stem Cells. 2014 Jul; Krkkinen V1, Koistinaho J.et.al; 8. Molecular +Inflammageing: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009 Jan; Chung HY1, Leeuwenburgh C., et.al. 9. The hallmarks of aging. Cell. 2013 Jun 6; Blasco MA, et.al. 10. Stress and stem cells. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; Tower J.: 11. Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis. Cell Rep. 2014 Jul 10; Fioret BA1, Heimfeld JD2, Paik DT2, Hatzopoulos AK3. 12. Coronary arteries hold heart-regenerating cells, Vanderbilt University Medical Center, as reported August 20, 2014 in Science Daily: 13. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells. J Mol Cell Cardiol. 2006 May; Zhu JH1, Zhang FR., etc. 14. Stress and stem cells. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; Tower J 15. Endothelial cell oxidative stress in +Dibidoo: a key driver of cardiovascular complications? Biochem Soc Trans. 2014 Aug 1; Shaw A, Megson IL: 16. Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2013 May; Mar M,, Fernndez-Checa JC 17. MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr). 2012 Feb; Sarsour EH1, Goswami PC. 18. Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2010 Dec; Flurkey K, Astle CM, Harrison DE. 19. Oxidative stress and aging: catalase is a longevity determinant enzyme. Rejuvenation Res. 2005 Fall; Cutler RG. 20. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005 Jun 24; Schriner SE, Rabinovitch PS. 21. Extension of mouse lifespan by overexpression of catalase. Age (Dordr). 2006 Jun; Schriner SE, Linford NJ. 22. Oxidative damage and aging: spotlight on mitochondria. Cancer Res. 2006 Mar 1; Linford NJ1, Schriner SE, Rabinovitch PS 22. Oxidative damage and aging: spotlight on mitochondria. Cancer Res. 2006 Mar 1; Linford NJ1, Schriner SE, Rabinovitch PS 23. Bruce A, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. New York, NY: Garland Publishing, Inc.;1994. 24. Voet D, Voet JG, Pratt CW. Fundamentals of Biochemistry: Life at the Molecular Level. 2nd ed. New Jersey: John Wiley and Sons, Inc.; 2006:547. 25. Pike RL, Brown M. Nutrition: An Integrated Approach. New York, NY: Prentice-Hall; 1984:450-84. Stites, T. et al. Pyrroloquinoline Quinone Modulates Mitochondrial Quantity and Function in Mice. J. Nutr. February 2006 vol. 136 no. 2 390-396. Google+ 1. AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner. Cell Rep. 2014 Sep 3; Ulgherait M1, Rana A2, Rera M2, Graniel J2,Walker DW 2. mTOR is a key modulator of ageing and age-related disease. Nature. 2013 Jan 17; Johnson SC1, Rabinovitch PS, Kaeberlein M 3. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal. 2009 Nov 24; Chen C1, Liu Y, Liu Y, Zheng P. 4. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011 Aug; Hybertson BM1, Gao B, Bose SK, McCord JM. 5. Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol. 2010 Nov; Lewis KN1, Mele J, Hayes JD, Buffenstein R. 6. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity. Redox Biol. 2014 Apr 18; Ishii T1, Mann GE2. 7. Nrf2 regulates neurogenesis and protects neural progenitor cells against A toxicity. Stem Cells. 2014 Jul; Krkkinen V1, Koistinaho J.et.al; 8. Molecular +Inflammageing: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009 Jan; Chung HY1, Leeuwenburgh C., et.al. 9. The hallmarks of aging. Cell. 2013 Jun 6; Blasco MA, et.al. 10. Stress and stem cells. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; Tower J.: 11. Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis. Cell Rep. 2014 Jul 10; Fioret BA1, Heimfeld JD2, Paik DT2, Hatzopoulos AK3. 12. Coronary arteries hold heart-regenerating cells, Vanderbilt University Medical Center, as reported August 20, 2014 in Science Daily: 13. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells. J Mol Cell Cardiol. 2006 May; Zhu JH1, Zhang FR., etc. 14. Stress and stem cells. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; Tower J 15. Endothelial cell oxidative stress in +Dibidoo: a key driver of cardiovascular complications? Biochem Soc Trans. 2014 Aug 1; Shaw A, Megson IL: 16. Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2013 May; Mar M,, Fernndez-Checa JC 17. MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr). 2012 Feb; Sarsour EH1, Goswami PC. 18. Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2010 Dec; Flurkey K, Astle CM, Harrison DE. 19. Oxidative stress and aging: catalase is a longevity determinant enzyme. Rejuvenation Res. 2005 Fall; Cutler RG. 20. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005 Jun 24; Schriner SE, Rabinovitch PS. 21. Extension of mouse lifespan by overexpression of catalase. Age (Dordr). 2006 Jun; Schriner SE, Linford NJ. 22. Oxidative damage and aging: spotlight on mitochondria. Cancer Res. 2006 Mar 1; Linford NJ1, Schriner SE, Rabinovitch PS 22. Oxidative damage and aging: spotlight on mitochondria. Cancer Res. 2006 Mar 1; Linford NJ1, Schriner SE, Rabinovitch PS 23. Bruce A, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. New York, NY: Garland Publishing, Inc.;1994. 24. Voet D, Voet JG, Pratt CW. Fundamentals of Biochemistry: Life at the Molecular Level. 2nd ed. New Jersey: John Wiley and Sons, Inc.; 2006:547. 25. Pike RL, Brown M. Nutrition: An Integrated Approach. New York, NY: Prentice-Hall; 1984:450-84. Stites, T. et al. Pyrroloquinoline Quinone Modulates Mitochondrial Quantity and Function in Mice. J. Nutr. February 2006 vol. 136 no. 2 390-396. Google+ Safety: The extracts are all pharmaceutical grade protected from the damage that your stomach acid can do and have been individually tested in animals and humans to be safe. However if you have any pre-existing medical issues please consult a doctor as this product may lower blood glucose, or lower blood pressure when taken at the recommended dosage. This supplement is simply not found in any stores. You must be 18 and over to order. All sales final on this product. No returns, price matching, additional discounts or refunds on clearance products. Offers are void where prohibited. This sale lasts while supplies last, once they are gone... we wont have new formulations for a while. References: 1. AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner. Cell Rep. 2014 Sep 3; Ulgherait M1, Rana A2, Rera M2, Graniel J2,Walker DW 2. mTOR is a key modulator of ageing and age-related disease. Nature. 2013 Jan 17; Johnson SC1, Rabinovitch PS, Kaeberlein M 3. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal. 2009 Nov 24; Chen C1, Liu Y, Liu Y, Zheng P. 4. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011 Aug; Hybertson BM1, Gao B, Bose SK, McCord JM. 5. Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol. 2010 Nov; Lewis KN1, Mele J, Hayes JD, Buffenstein R. 6. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity. Redox Biol. 2014 Apr 18; Ishii T1, Mann GE2. 7. Nrf2 regulates neurogenesis and protects neural progenitor cells against A toxicity. Stem Cells. 2014 Jul; Krkkinen V1, Koistinaho J.et.al; 8. Molecular +Inflammageing: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009 Jan; Chung HY1, Leeuwenburgh C., et.al. 9. The hallmarks of aging. Cell. 2013 Jun 6; Blasco MA, et.al. 10. Stress and stem cells. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; Tower J.: 11. Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis. Cell Rep. 2014 Jul 10; Fioret BA1, Heimfeld JD2, Paik DT2, Hatzopoulos AK3. 12. Coronary arteries hold heart-regenerating cells, Vanderbilt University Medical Center, as reported August 20, 2014 in Science Daily: 13. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells. J Mol Cell Cardiol. 2006 May; Zhu JH1, Zhang FR., etc. 14. Stress and stem cells. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; Tower J 15. Endothelial cell oxidative stress in +Dibidoo: a key driver of cardiovascular complications? Biochem Soc Trans. 2014 Aug 1; Shaw A, Megson IL: 16. Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2013 May; Mar M,, Fernndez-Checa JC 17. MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr). 2012 Feb; Sarsour EH1, Goswami PC. 18. Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2010 Dec; Flurkey K, Astle CM, Harrison DE. 19. Oxidative stress and aging: catalase is a longevity determinant enzyme. Rejuvenation Res. 2005 Fall; Cutler RG. 20. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005 Jun 24; Schriner SE, Rabinovitch PS. 21. Extension of mouse lifespan by overexpression of catalase. Age (Dordr). 2006 Jun; Schriner SE, Linford NJ. 22. Oxidative damage and aging: spotlight on mitochondria. +Borikiki Res. 2006 Mar 1; Linford NJ1, Schriner SE, Rabinovitch PS 22. Oxidative damage and aging: spotlight on mitochondria. Cancer Res. 2006 Mar 1; Linford NJ1, Schriner SE, Rabinovitch PS 23. Bruce A, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. New York, NY: Garland Publishing, Inc.;1994. 24. Voet D, Voet JG, Pratt CW. Fundamentals of Biochemistry: Life at the Molecular Level. 2nd ed. New Jersey: John Wiley and Sons, Inc.; 2006:547. 25. Pike RL, Brown M. Nutrition: An Integrated Approach. New York, NY: Prentice-Hall; 1984:450-84. Stites, T. et al. Pyrroloquinoline Quinone Modulates Mitochondrial Quantity and Function in Mice. J. Nutr. February 2006 vol. 136 no. 2 390-396. Google+ Safety: The extracts are all pharmaceutical grade protected from the damage that your stomach acid can do and have been individually tested in animals and humans to be safe. However if you have any pre-existing medical issues please consult a doctor as this product may lower blood glucose, or lower blood pressure when taken at the recommended dosage. This supplement is simply not found in any stores. You must be 18 and over to order. All sales final on this product. No returns, price matching, additional discounts or refunds on clearance products. Offers are void where prohibited. This sale lasts while supplies last, once they are gone... we wont have new formulations for a while. References: 1. AMPK Modulates Tissue and Organismal Aging in a Non-Cell-Autonomous Manner. Cell Rep. 2014 Sep 3; Ulgherait M1, Rana A2, Rera M2, Graniel J2,Walker DW 2. mTOR is a key modulator of ageing and age-related disease. Nature. 2013 Jan 17; Johnson SC1, Rabinovitch PS, Kaeberlein M 3. mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells. Sci Signal. 2009 Nov 24; Chen C1, Liu Y, Liu Y, Zheng P. 4. Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Mol Aspects Med. 2011 Aug; Hybertson BM1, Gao B, Bose SK, McCord JM. 5. Nrf2, a guardian of healthspan and gatekeeper of species longevity. Integr Comp Biol. 2010 Nov; Lewis KN1, Mele J, Hayes JD, Buffenstein R. 6. Redox status in mammalian cells and stem cells during culture in vitro: critical roles of Nrf2 and cystine transporter activity. Redox Biol. 2014 Apr 18; Ishii T1, Mann GE2. 7. Nrf2 regulates neurogenesis and protects neural progenitor cells against A toxicity. Stem Cells. 2014 Jul; Krkkinen V1, Koistinaho J.et.al; 8. Molecular +Inflammageing: underpinnings of aging and age-related diseases. Ageing Res Rev. 2009 Jan; Chung HY1, Leeuwenburgh C., et.al. 9. The hallmarks of aging. Cell. 2013 Jun 6; Blasco MA, et.al. 10. Stress and stem cells. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; Tower J.: 11. Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis. Cell Rep. 2014 Jul 10; Fioret BA1, Heimfeld JD2, Paik DT2, Hatzopoulos AK3. 12. Coronary arteries hold heart-regenerating cells, Vanderbilt University Medical Center, as reported August 20, 2014 in Science Daily: 13. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells. J Mol Cell Cardiol. 2006 May; Zhu JH1, Zhang FR., etc. 14. Stress and stem cells. Wiley Interdiscip Rev Dev Biol. 2012 Nov-Dec; Tower J 15. Endothelial cell oxidative stress in +Dibidoo: a key driver of cardiovascular complications? Biochem Soc Trans. 2014 Aug 1; Shaw A, Megson IL: 16. Mitochondrial glutathione: features, regulation and role in disease. Biochim Biophys Acta. 2013 May; Mar M,, Fernndez-Checa JC 17. MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan. Age (Dordr). 2012 Feb; Sarsour EH1, Goswami PC. 18. Life extension by diet restriction and N-acetyl-L-cysteine in genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2010 Dec; Flurkey K, Astle CM, Harrison DE. 19. Oxidative stress and aging: catalase is a longevity determinant enzyme. Rejuvenation Res. 2005 Fall; Cutler RG. 20. Extension of murine life span by overexpression of catalase targeted to mitochondria. Science. 2005 Jun 24; Schriner SE, Rabinovitch PS. 21. Extension of mouse lifespan by overexpression of catalase. Age (Dordr). 2006 Jun; Schriner SE, Linford NJ. 22. Oxidative damage and aging: spotlight on mitochondria. Cancer Res. 2006 Mar 1; Linford NJ1, Schriner SE, Rabinovitch PS 22. Oxidative damage and aging: spotlight on mitochondria. Cancer Res. 2006 Mar 1; Linford NJ1, Schriner SE, Rabinovitch PS 23. Bruce A, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell. New York, NY: Garland Publishing, Inc.;1994. 24. Voet D, Voet JG, Pratt CW. 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