Dry eye is one of the most common eye diseases that cause much discomfort for those suffering from it. +Inflammageing and high concentrations of salt in tears - can cause a harmful condition known as hyperosmolarity, which can cause cells to pour water and cause corneal injury and visual impairment. Dry eye treatment procedures include eye drops containing artificial tears designed to reduce discomfort. Studies have shown that the chemical NMN (Nicotinamide Mononucleotide) provides cell protection for eye disorders such as retinal detachment. Thus, it is vital to determine whether it is applicable to dry eye disorders.
Researchers in China have published a paper in the Journal of +Inflammageing Research describing how treating mouse eye cells exposed to salt-induced hyperosmolarity using NMNs keeps them viable. NMN (Nicotinamide Mononucleotide) reduces the eye's +Inflammageing degree after exposure to hyperosmolarity by activating a protein involved in DNA metabolism and maintaining its integrity known as Sirtuin1 (SIRT1). According to their research, NMN Food (Nicotinamide Mononucleotide) also orchestrates eye immune cells to move from an era of cellular death and elimination to a state of healing. If these results can be translated into the human body, NMN Food (Nicotinamide Mononucleotide) could provide a method to prevent eye injuries due to dryness.
What about RevGenetics Products? RevGenetics products are only made for overall health and optimization* we don't make any medical claims as human studies have not been done regarding the information in this article. We provide a high-purity Nicotinamide Mononucleotide for University research labs to do human studies, and as a dietary supplement. Click to learn more about Advanced NMN Foods!
How Does NMN Protect Against Dry Eye Disease?
NMN (Nicotinamide Mononucleotide) increases the concentrations of the critical molecule nicotinamide dinucleotide (NAD), which is involved in energy-generating cellular reactions. SIRT1 uses SIRT1 to perform its functions in maintaining a healthy metabolism and maintaining DNA integrity. Researchers believe that by increasing NAD levels, NMN (Nicotinamide Mononucleotide) helps protect eye cells from damage in retinal detachment. To this end, it is essential to discover the role of NMN (Nicotinamide Mononucleotide) in dry eye disease and the mechanisms it affects. [1]
NMN Improves Eye Cell Survival Under Dry Eye Situations
To test whether NMN (Nicotinamide Mononucleotide) helps protect the mouse eye cells from a hyperosmotic environment in a laboratory dish induced by salt, researchers treated them with 500 uM NMN Food (Nicotinamide Mononucleotide) and evaluated their survival. The research team discovered that treatment with NMN Food (Nicotinamide Mononucleotide) prevented cell death because of hyperosmotic stress. This suggests that NMN Food (Nicotinamide Mononucleotide) is a powerful protective effect on the eye cells under hyperosmotic pressure in situations resembling dry eye disease. [2]
NMN Activates SIRT1 to Protect Eye Cells
Researchers also looked at how NMN Food (Nicotinamide Mononucleotide) can decrease +Inflammageing. They found that NMN (Nicotinamide Mononucleotide) reduces the levels of inflammatory substance IL-17a in hyperosmotic stress conditions. The researchers also found that SIRT1 levels increased with NMN Food (Nicotinamide Mononucleotide) treatment under hyperosmotic conditions and that using the SIRT1 inhibitor increased the levels of +Inflammageing markers. The results indicate that NMN (Nicotinamide Mononucleotide) diminishes +Inflammageing in hyperosmotic conditions by stimulating and increasing SIRT1. [3]
NMN Facilitates an Immune Cell Healing Response
To better understand how NMN Food (Nicotinamide Mononucleotide) helps protect the eye cell, researchers looked into the impact of NMN (Nicotinamide Mononucleotide), as well as an antagonist of +Inflammageing marker IL-17a, on the status of macrophages and the immune system. They are found in two different states. When macrophages are in the M1 condition, they are prone to kill the cells within their vicinity, and when they are in the state of M2, they repair the cells close to them. The researchers found that a hyperosmotic environment increased destructive macrophages and diminished the healing capacity of M1 macrophages. NMN (Nicotinamide Mononucleotide) and IL-17a inhibitors stimulated the healing of M2 macrophages under similar conditions. These studies show that NMN (Nicotinamide Mononucleotide) inhibits macrophage removal and facilitates healing by blocking a vital marker and +Inflammageing motor called IL-17a. [4]
Can NMN Help Human Dry Eye Disease?
Future studies of NMN (Nicotinamide Mononucleotide) in human cell lines will show whether patients can use this medication to protect against hyperosmolarity associated with dry eye diseases. If so, NMN (Nicotinamide Mononucleotide) treatment and artificial tear drops can slow the progression of the injuries resulting from the common eye condition. [5]
Are you a University lab, and would you like to do a human study? We provide a high-purity Nicotinamide Mononucleotide for University research labs and as a dietary supplement. Click to learn more about Advanced NMN Foods!
References:
https://link.springer.com/article/10.1007/s11033-022-07459-1
https://www.sciencedirect.com/science/article/pii/S0753332222000476
https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.14360
https://www.nature.com/articles/s43587-022-00172-5
